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S6A12 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - S6A12 Antibody (N-term) AP10503a
    S6A12 Antibody (N-term) (Cat. #AP10503a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the S6A12 antibody detected the S6A12 protein (arrow).
  • 4 - S6A12 Antibody (N-term) AP10503a
    S6A12 Antibody (N-term) (Cat. #AP10503a) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession P48065
Other Accession NP_003035.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 69368 Da
Additional info
Gene ID 6539
Other Names Sodium- and chloride-dependent betaine transporter, BGT-1, Na(+)/Cl(-) betaine/GABA transporter, Solute carrier family 6 member 12, SLC6A12
Target/Specificity This S6A12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human S6A12.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsS6A12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC6A12
Function Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain
Research Areas

BACKGROUND

Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

REFERENCES

Pasaje, C.F., et al. Ann. Hum. Genet. 74(4):326-334(2010) Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010) Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) : Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009) Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :

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