|Application ||WB, FC, E|
|Calculated MW||69368 Da|
|Other Names||Sodium- and chloride-dependent betaine transporter, BGT-1, Na(+)/Cl(-) betaine/GABA transporter, Solute carrier family 6 member 12, SLC6A12|
|Target/Specificity||This S6A12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human S6A12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||S6A12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain|
Provided below are standard protocols that you may find useful for product applications.
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
Pasaje, C.F., et al. Ann. Hum. Genet. 74(4):326-334(2010) Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010) Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) : Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009) Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :