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MICALL1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MICALL1 Antibody (C-term) AP10498a
    MICALL1 Antibody (C-term) (Cat. #AP10498a) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the MICALL1 antibody detected the LACRT protein (arrow).
  • 14 - MICALL1 Antibody (C-term) AP10498a
    MICALL1 Antibody (C-term) (Cat. #AP10498a) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MICALL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q8N3F8
Other Accession NP_203744.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 93441 Da
Additional info
Gene ID 85377
Other Names MICAL-like protein 1, Molecule interacting with Rab13, MIRab13, MICALL1, KIAA1668, MIRAB13
Target/Specificity This MICALL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-781 amino acids from the C-terminal region of human MICALL1.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMICALL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MICALL1
Synonyms KIAA1668, MIRAB13
Function Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
Cellular Location Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6
Research Areas

BACKGROUND

MICALL1 may be a cytoskeletal regulator.

REFERENCES

Sharma, M., et al. Mol. Biol. Cell 20(24):5181-5194(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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