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>   首页   >   产品   >   一抗   >   精选抗体   >   G蛋白偶联受体抗体(GPCR)   >   CCR8 Antibody (C-term)   

CCR8 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CCR8 Antibody (C-term) AP10485b
    CCR8 Antibody (C-term) (Cat. #AP10485b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CCR8 antibody detected the CCR8 protein (arrow).
  • 4 - CCR8 Antibody (C-term) AP10485b
    CCR8 Antibody (C-term) (Cat. #AP10485b) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession P51685
Other Accession NP_005192.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40844 Da
Additional info
Gene ID 1237
Other Names C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, CMKBRL2, Chemokine receptor-like 1, CKR-L1, GPR-CY6, GPRCY6, TER1, CDw198, CCR8, CKRL1, CMKBR8, CMKBRL2
Target/Specificity This CCR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-317 amino acids from the C-terminal region of human CCR8.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCR8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR8
Synonyms CKRL1, CMKBR8, CMKBRL2
Function Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas

BACKGROUND

CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. CCR8 is located at the chemokine receptor gene cluster region.

REFERENCES

Mutalithas, K., et al. Clin. Exp. Allergy 40(8):1175-1185(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)

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