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ABCD1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ABCD1 Antibody (Center) AP10454c
    All lanes : Anti-ABCD1 Antibody (Center) at 1:2000 dilution Lane 1: 293T/17 whole cell lysate Lane 2: HL-60 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 83 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - ABCD1 Antibody (Center) AP10454c
    ABCD1 Antibody (Center) (Cat. #AP10454c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ABCD1 antibody detected the ABCD1 protein (arrow).
  • 14 - ABCD1 Antibody (Center) AP10454c
    ABCD1 antibody (Center) (Cat. #AP10454c) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCD1 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - ABCD1 Antibody (Center) AP10454c
    ABCD1 Antibody (Center) (Cat. #AP10454c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession P33897
Other Accession P48410, NP_000024.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 82937 Da
Additional info
Gene ID 215
Other Names ATP-binding cassette sub-family D member 1, Adrenoleukodystrophy protein, ALDP, ABCD1, ALD
Target/Specificity This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsABCD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCD1
Synonyms ALD
Function Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Cellular Location Peroxisome membrane; Multi-pass membrane protein
Research Areas

BACKGROUND

ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.

REFERENCES

Matsukawa, T., et al. Neurogenetics (2010) In press :
Xie, H.H., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(2):144-148(2010)
Li, J.Y., et al. J. Neurol. Sci. 290 (1-2), 163-165 (2010) :
Hour, T.C., et al. Int. J. Biol. Markers 24(3):171-178(2009)
Shukla, P., et al. J. Child Neurol. 24(7):857-860(2009)

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