|Application ||WB, FC, E|
|Other Accession||P61622, NP_001004439.1|
|Reactivity||Human, Mouse, Hamster|
|Other Names||Integrin alpha-11, ITGA11|
|Target/Specificity||This ITGA11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from the N-terminal region of human ITGA11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ITGA11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-11/beta-1 is a receptor for collagen.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Lu, N., et al. Matrix Biol. 29(3):166-176(2010) Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009) Young, R.P., et al. Postgrad Med J 85(1008):515-524(2009) Barczyk, M.M., et al. J. Dent. Res. 88(7):621-626(2009)