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SYT8 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SYT8 Antibody (Center) AP10354c
    SYT8 Antibody (Center) (Cat. #AP10354c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SYT8 antibody detected the SYT8 protein (arrow).
  • 14 - SYT8 Antibody (Center) AP10354c
    SYT8 antibody (Center) (Cat. #AP10354c) immunohistochemistry analysis in formalin fixed and paraffin embedded human Placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the SYT8 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q8NBV8
Other Accession NP_612634.3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44138 Da
Additional info
Gene ID 90019
Other Names Synaptotagmin-8, Synaptotagmin VIII, SytVIII, SYT8
Target/Specificity This SYT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from the Central region of human SYT8.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYT8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYT8
Function Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity).
Cellular Location Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome
Research Areas

BACKGROUND

Synaptotagmins, such as SYT8, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.

REFERENCES

Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Li, C., et al. Nature 375(6532):594-599(1995)

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