|Application ||WB, IHC-P, E|
|Calculated MW||44138 Da|
|Other Names||Synaptotagmin-8, Synaptotagmin VIII, SytVIII, SYT8|
|Target/Specificity||This SYT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from the Central region of human SYT8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYT8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity).|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome|
Provided below are standard protocols that you may find useful for product applications.
Synaptotagmins, such as SYT8, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Li, C., et al. Nature 375(6532):594-599(1995)