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SLC25A12 Antibody (N-Term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SLC25A12 Antibody (N-Term) AP10273a
    SLC25A12 Antibody (N-Term) (Cat. #AP10273a) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the SLC25A12 antibody detected SLC25A12 protein (arrow).
  • 14 - SLC25A12 Antibody (N-Term) AP10273a
    SLC25A12 antibody (N-Term) (Cat. #AP10273a) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC25A12 antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession O75746
Other Accession NP_003696.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 74762 Da
Additional info
Gene ID 8604
Other Names Calcium-binding mitochondrial carrier protein Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, SLC25A12, ARALAR1
Target/Specificity This SLC25A12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC25A12.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLC25A12 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC25A12
Synonyms ARALAR1
Function Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Tissue Location Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney
Research Areas

BACKGROUND

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in the gene encoding this protein may be associated with risk of autism. [provided by RefSeq].

REFERENCES

Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Chien, W.H., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(1):189-192(2010)
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
Marmol, P., et al. J. Biol. Chem. 284(1):515-524(2009)
Turunen, J.A., et al. Autism Res 1(3):189-192(2008)

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