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CLDN22 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CLDN22 Antibody (Center) AP10232c
    CLDN22 Antibody (Center) (Cat. #AP10232c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CLDN22 antibody detected the CLDN22 protein (arrow).
  • 1 - CLDN22 Antibody (Center) AP10232c
    CLDN22 Antibody (Center) (Cat. #AP10232c) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the CLDN22 antibody detected the CLDN22 protein (arrow).
  • 4 - CLDN22 Antibody (Center) AP10232c
    CLDN22 Antibody (Center) (Cat. #AP10232c) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession Q8N7P3
Other Accession A6NM45, NP_001104789.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 24509 Da
Additional info
Gene ID 53842
Other Names Claudin-22, CLDN22
Target/Specificity This CLDN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the Central region of human CLDN22.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLDN22 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLDN22
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.
Cellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Research Areas

BACKGROUND

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.

REFERENCES

Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
Krause, G., et al. Biochim. Biophys. Acta 1778(3):631-645(2008)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Katoh, M., et al. Int. J. Mol. Med. 11(6):683-689(2003)
Gonzalez-Mariscal, L., et al. Prog. Biophys. Mol. Biol. 81(1):1-44(2003)

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