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IKZF1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - IKZF1 Antibody (C-term) AP10222B
    IKZF1 Antibody (C-term) (Cat. #AP10222b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the IKZF1 antibody detected the IKZF1 protein (arrow).
  • 14 - IKZF1 Antibody (C-term) AP10222B
    IKZF1 Antibody (C-term) (Cat. #AP10222b) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IKZF1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - IKZF1 Antibody (C-term) AP10222B
    IKZF1 Antibody (C-term) (Cat. #AP10222b) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession Q13422
Other Accession NP_006051.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57528 Da
Additional info
Gene ID 10320
Other Names DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF-1, IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Target/Specificity This IKZF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-444 amino acids from the C-terminal region of human IKZF1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIKZF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IKZF1
Synonyms IK1, IKAROS, LYF1, ZNFN1A1
Function Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta- globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).
Cellular Location Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events Isoform Ik6: Cytoplasm.
Tissue Location Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.
Research Areas
Activation of c-Abl kinase potentiates the anti-myeloma drug lenalidomide by promoting DDA1 recruitment to the CRL4 ubiquitin ligase.
Author : Gao S1,Geng C1,Song T1,Lin X2,Liu J1,Cai Z2,Cang Y3.
J Biol Chem. 2017 Jan 13. pii: jbc.M116.761551. doi: 10.1074/jbc.M116.761551. [Epub ahead of print]
28087699

REFERENCES

He, C.F., et al. Lupus 19(10):1181-1186(2010)
Yang, L., et al. Oncol. Rep. 24(2):571-577(2010)
Jager, R., et al. Leukemia 24(7):1290-1298(2010)
Kuiper, R.P., et al. Leukemia 24(7):1258-1264(2010)
Matulic, M., et al. Coll Antropol 34(1):59-62(2010)

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