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>   首页   >   产品   >   一抗   >   信号转导   >   GCC2 Antibody (C-term)   

GCC2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GCC2 Antibody (C-term) AP10197b
    GCC2 Antibody (C-term) (Cat. #AP10197b) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the GCC2 antibody detected GCC2 protein (arrow).
  • 14 - GCC2 Antibody (C-term) AP10197b
    GCC2 antibody (C-term) (Cat. #AP10197b) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GCC2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q8IWJ2
Other Accession O14715, Q99666, D3ZZL9, Q8CHG3, NP_852118.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 195910 Da
Additional info
Gene ID 9648
Other Names GRIP and coiled-coil domain-containing protein 2, 185 kDa Golgi coiled-coil protein, GCC185, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, RanBP2L4, Renal carcinoma antigen NY-REN-53, GCC2, KIAA0336, RANBP2L4
Target/Specificity This GCC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1581-1609 amino acids from the C-terminal region of human GCC2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGCC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCC2
Synonyms KIAA0336, RANBP2L4
Function Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Cellular Location Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein
Tissue Location Ubiquitous..
Research Areas

BACKGROUND

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants.

REFERENCES

Houghton, F.J., et al. Cell 138(4):787-794(2009)
Hayes, G.L., et al. Mol. Biol. Cell 20(1):209-217(2009)
Burguete, A.S., et al. Cell 132(2):286-298(2008)
Efimov, A., et al. Dev. Cell 12(6):917-930(2007)
Derby, M.C., et al. Traffic 8(6):758-773(2007)

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