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HSPA9 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - HSPA9 Antibody (Center) AP10160c
    HSPA9 Antibody (Center) (Cat. #AP10160c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HSPA9 antibody detected the HSPA9 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P38646
Other Accession P48721, P38647, O35501, Q3ZCH0, NP_004125.3
Reactivity Human
Predicted Bovine, Hamster, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 73680 Da
Additional info
Gene ID 3313
Other Names Stress-70 protein, mitochondrial, 75 kDa glucose-regulated protein, GRP-75, Heat shock 70 kDa protein 9, Mortalin, MOT, Peptide-binding protein 74, PBP74, HSPA9, GRP75, HSPA9B, mt-HSP70
Target/Specificity This HSPA9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-301 amino acids from the Central region of human HSPA9.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSPA9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPA9
Synonyms GRP75, HSPA9B, mt-HSP70
Function Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity).
Cellular Location Mitochondrion. Nucleus, nucleolus
Research Areas

BACKGROUND

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.

REFERENCES

Li, Y., et al. Environ. Health Perspect. 118(7):936-942(2010)
Luo, W.I., et al. Protein Expr. Purif. 72(1):75-81(2010)
Goswami, A.V., et al. J. Biol. Chem. 285(25):19472-19482(2010)
Iosefson, O., et al. FEBS Lett. 584(6):1080-1084(2010)
Rikova, K., et al. Cell 131(6):1190-1203(2007)

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