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TIMP4 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - TIMP4 Antibody (Center) AP10148c
    TIMP4 Antibody (Center) (Cat. #AP10148c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TIMP4 antibody detected the TIMP4 protein (arrow).
  • 1 - TIMP4 Antibody (Center) AP10148c
    TIMP4 Antibody (Center) (Cat. #AP10148c) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the TIMP4 antibody detected the TIMP4 protein (arrow).
  • 14 - TIMP4 Antibody (Center) AP10148c
    TIMP4 Antibody (Center) (Cat. #AP10148c) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TIMP4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q99727
Other Accession NP_003247.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 25503 Da
Additional info
Gene ID 7079
Other Names Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4, TIMP-4, TIMP4
Target/Specificity This TIMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the Central region of human TIMP4.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTIMP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIMP4
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.
Cellular Location Secreted.
Tissue Location Abundant in heart and present at low levels in many other tissues
Research Areas

BACKGROUND

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.

REFERENCES

Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Wojciechowski, R., et al. Invest. Ophthalmol. Vis. Sci. (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liss, M., et al. Am. J. Pathol. 175(3):940-946(2009)

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