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TFB2M Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 14 - TFB2M Antibody (C-term) AP10145b
    TFB2M Antibody (C-term) (Cat. #AP10145b) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TFB2M Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 1 - TFB2M Antibody (C-term) AP10145b
    TFB2M Antibody (C-term) (Cat. #AP10145b) western blot analysis in K562,WiDr cell line lysates (35ug/lane).This demonstrates the TFB2M antibody detected the TFB2M protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession Q9H5Q4
Other Accession NP_071761.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 45349 Da
Additional info
Gene ID 64216
Other Names Dimethyladenosine transferase 2, mitochondrial, 211-, Hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, h-mtTFB, h-mtTFB2, hTFB2M, mtTFB2, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, TFB2M, NS5ATP5
Target/Specificity This TFB2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human TFB2M.
Dilution IHC-P~~1:50~100
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTFB2M Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFB2M
Synonyms NS5ATP5
Function S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
Cellular Location Mitochondrion.
Tissue Location Ubiquitously expressed.
Research Areas

REFERENCES

Litonin, D., et al. J. Biol. Chem. 285(24):18129-18133(2010)
Norrbom, J., et al. Acta Physiol (Oxf) 198(1):71-79(2010)
Fukuoh, A., et al. Genes Cells 14(8):1029-1042(2009)
Cotney, J., et al. Hum. Mol. Genet. 18(14):2670-2682(2009)
Alonso-Montes, C., et al. Dis. Markers 25(3):131-139(2008)

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