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MUTED Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MUTED Antibody (Center) AP10139c
    MUTED Antibody (Center) (Cat. #AP10139c) western blot analysis in MDA-MB435 cell line lysates (15ug/lane).This demonstrates the MUTED antibody detected MUTED protein (arrow).
  • 1 - MUTED Antibody (Center) AP10139c
    MUTED Antibody (Center) (Cat. #AP10139c) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the MUTED antibody detected MUTED protein (arrow).
  • 14 - MUTED Antibody (Center) AP10139c
    MUTED Antibody (Center) (Cat. #AP10139c) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MUTED Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q8TDH9
Other Accession A5A777, NP_958437.1
Reactivity Human, Mouse
Predicted Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21609 Da
Additional info
Gene ID 63915
Other Names Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog, BLOC1S5, MUTED
Target/Specificity This MUTED antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the Central region of human MUTED.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMUTED Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BLOC1S5
Synonyms MUTED
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Research Areas

BACKGROUND

This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene.

REFERENCES

Morris, D.W., et al. Biol. Psychiatry 63(1):24-31(2008)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Starcevic, M., et al. J. Biol. Chem. 279(27):28393-28401(2004)
Li, W., et al. Nat. Genet. 35(1):84-89(2003)
Ciciotte, S.L., et al. Blood 101(11):4402-4407(2003)

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