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BTG2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BTG2 Antibody (N-term) AP10121a
    BTG2 Antibody (N-term) (Cat. #AP10121a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the BTG2 antibody detected the BTG2 protein (arrow).
  • 14 - BTG2 Antibody (N-term) AP10121a
    BTG2 Antibody (N-term) (Cat. #AP10121a)immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BTG2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P78543
Other Accession NP_006754.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 17416 Da
Additional info
Gene ID 7832
Other Names Protein BTG2, BTG family member 2, NGF-inducible anti-proliferative protein PC3, BTG2, PC3
Target/Specificity This BTG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human BTG2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBTG2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BTG2
Synonyms PC3
Function Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
Research Areas
Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell carcinoma cells.
Author : Lee JC1, Chung LC2, Chen YJ3, Feng TH4, Chen WT5, Juang HH6.
Cancer Lett. 2015 Feb 23. pii: S0304-3835(15)00138-X. doi: 10.1016/j.canlet.2015.02.034. [Epub ahead of print]
25721086

BACKGROUND

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle.

REFERENCES

Zhang, L., et al. Mol. Biol. Rep. 37(6):2579-2586(2010)
Mollerstrom, E., et al. BMC Cancer 10, 296 (2010) :
Park, T.J., et al. Exp. Cell Res. 315(18):3152-3162(2009)
Liu, M., et al. Cell Res. 19(7):828-837(2009)
Farioli-Vecchioli, S., et al. PLoS ONE 4 (12), E8339 (2009) :

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