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>   首页   >   产品   >   一抗   >   细胞生物学   >   ADAMTS10 Antibody (N-term)   

ADAMTS10 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ADAMTS10 Antibody (N-term) AP10102a
    ADAMTS10 Antibody (N-term) (Cat. #AP10102a) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the ADAMTS10 antibody detected the ADAMTS10 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9H324
Other Accession NP_112219.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 120874 Da
Additional info
Gene ID 81794
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 10, ADAM-TS 10, ADAM-TS10, ADAMTS-10, 3424-, ADAMTS10
Target/Specificity This ADAMTS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the N-terminal region of human ADAMTS10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADAMTS10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAMTS10
Function Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Widely expressed in adult tissues.
Research Areas

BACKGROUND

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.

REFERENCES

Morales, J., et al. Am. J. Hum. Genet. 85(5):558-568(2009)
Ben Yahia, S., et al. J. Hum. Genet. 54(9):550-553(2009)
Kutz, W.E., et al. Hum. Mutat. 29(12):1425-1434(2008)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Dagoneau, N., et al. Am. J. Hum. Genet. 75(5):801-806(2004)

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