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ADAMTS4 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - ADAMTS4 Antibody AM8671b
    Anti-ADAMTS4 Antibody at 1:8000 dilution + Recombinant protein Lysates/proteins at 20ng per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 90 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O75173
Reactivity Human
Predicted Human
Host Mouse
Clonality monoclonal
Isotype IgG1,κ
Clone Names 1995CT113.89.78
Calculated MW 90197 Da
Additional info
Gene ID 9507
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688
Target/Specificity This ADAMTS4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human ADAMTS4.
Dilution WB~~1:8000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADAMTS4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAMTS4
Synonyms KIAA0688
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium
Research Areas

BACKGROUND

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

REFERENCES

Tortorella M.D.,et al.Science 284:1664-1666(1999).
Wainwright S.D.,et al.Matrix Biol. 25:317-320(2006).
Sawaji Y.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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