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TXN Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - TXN Antibody AM8661b
    All lanes : Anti-TXN at 1:2000 dilution Lane 1: SH-SY5Y whole cell lysate Lane 2: A431 whole cell lysate Lane 3: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 12 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P10599
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1850CT339.14.1
Calculated MW 11737 Da
Additional info
Gene ID 7295
Other Names Thioredoxin, Trx, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP, TXN, TRDX, TRX, TRX1
Target/Specificity This antibody is generated from a mouse immunized with a recombinant protein from human.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTXN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXN
Synonyms TRDX, TRX, TRX1
Function Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Cellular Location Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus
Research Areas

BACKGROUND

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

REFERENCES

Wollman E.E.,et al.J. Biol. Chem. 263:15506-15512(1988).
Tagaya Y.,et al.EMBO J. 8:757-764(1989).
Tonissen K.F.,et al.Gene 102:221-228(1991).
Reddy P.G.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Liu A.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.

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