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ROS1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - ROS1 Antibody AM8639b
    Anti-ROS1 Antibody at 1:4000 dilution + Recombinant protein Lysates/proteins at 20ng per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 264 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P08922
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1843CT776.78.21
Calculated MW 263915 Da
Additional info
Gene ID 6098
Other Names Proto-oncogene tyrosine-protein kinase ROS, 2.7.10.1, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS
Target/Specificity This ROS1 antibody is generated from a mouse immunized with a recombinant protein of human ROS1.
Dilution WB~~1:4000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsROS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ROS1
Synonyms MCF3, ROS
Function Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in brain. Expression is increased in primary gliomas.
Research Areas

BACKGROUND

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

REFERENCES

Birchmeier C.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:4799-4803(1990).
Mungall A.J.,et al.Nature 425:805-811(2003).
Matsushime H.,et al.Mol. Cell. Biol. 6:3000-3004(1986).
Birchmeier C.,et al.Mol. Cell. Biol. 6:3109-3116(1986).
Watkins D.,et al.Cancer Genet. Cytogenet. 72:130-136(1994).

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