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HAVCR2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 4 - HAVCR2 Antibody AM8632b
    Overlay histogram showing U-2 OS cells stained with AM8632b(green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (AM8632b, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Mouse IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(NH174309) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was mouse IgG2b (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • 1 - HAVCR2 Antibody AM8632b
    All lanes : Anti-HAVCR2 Antibody at 1:4000 dilution Lane 1: HepG2 whole cell lysate Lane 2: Daudi whole cell lysate Lane 3: Human kidney lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 33 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, WB, E
Primary Accession Q8TDQ0
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG2b,k
Clone Names 1827CT151.74.68
Calculated MW 33394 Da
Additional info
Gene ID 84868
Other Names Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3
Target/Specificity This HAVCR2 antibody is generated from a mouse immunized with a recombinant protein of human HAVCR2.
Dilution FC~~1:25
WB~~1:4000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHAVCR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HAVCR2
Synonyms TIM3, TIMD3
Function Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location T-helper type 1 lymphocyte (Th1)-specific.
Research Areas

BACKGROUND

Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

REFERENCES

Monney L.,et al.Nature 415:536-541(2002).
Zhang W.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
Kuehn E.W.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).

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