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FDPS Antibody (Center)

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - FDPS Antibody (Center) AM8630b
    All lanes : Anti-FDPS Antibody (Center) at 1:2000-1:4000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: U-251 MG whole cell lysate Lane 4: Mouse Liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 40, 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P14324
Reactivity Human, Mouse
Host Mouse
Clonality monoclonal
Isotype IgG2b,k
Clone Names 1049CT13.1.4
Calculated MW 48275 Da
Additional info
Gene ID 2224
Other Names Farnesyl pyrophosphate synthase, FPP synthase, FPS, 2.5.1.10, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, 2.5.1.1, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Target/Specificity This FDPS antibody is generated from a mouse immunized with a recombinant protein of human FDPS.
Dilution WB~~1:2000-1:4000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFDPS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FDPS
Synonyms FPS, KIAA1293
Function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Cellular Location Cytoplasm.
Research Areas

BACKGROUND

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

REFERENCES

Wilkin D.J.,et al.J. Biol. Chem. 265:4607-4614(1990).
Nomura N.,et al.DNA Res. 1:27-35(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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