SMAD1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application ![]()
| IF, IHC-P, WB, E |
---|---|
Primary Accession | Q15797 |
Reactivity | Human |
Host | Mouse |
Clonality | monoclonal |
Isotype | IgG1,k |
Clone Names | 1356CT119.18.55 |
Calculated MW | 52260 Da |
Gene ID | 4086 |
---|---|
Other Names | Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1, SMAD1, BSP1, MADH1, MADR1 |
Target/Specificity | This SMAD1 antibody is generated from a mouse immunized with a recombinant protein between 20-330 amino acids from human SMAD1. |
Dilution | IF~~1:25 IHC-P~~1:25 WB~~1:2000 |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SMAD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SMAD1 |
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Synonyms | BSP1, MADH1, MADR1 |
Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. |
Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane |
Tissue Location | Ubiquitous. Highest expression seen in the heart and skeletal muscle |
Research Areas
BACKGROUND
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
REFERENCES
Riggins G.J.,et al.Nat. Genet. 13:347-349(1996).
Liu F.,et al.Nature 381:620-623(1996).
Hoodless P.A.,et al.Cell 85:489-500(1996).
Lechleider R.J.,et al.J. Biol. Chem. 271:17617-17620(1996).
Zhang Y.,et al.Nature 383:168-172(1996).

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