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RAB14 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - RAB14 Antibody AM8601b
    All lanes : Anti-RAB14 Antibody at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: Raji whole cell lysate Lane 3: human brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 24 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P61106
Other Accession Q5ZKU5, Q91V41, Q5R8Z8
Reactivity Human
Predicted Chicken, Mouse
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1779CT692.32.86
Calculated MW 23897 Da
Additional info
Gene ID 51552
Other Names Ras-related protein Rab-14, RAB14
Target/Specificity This RAB14 antibody is generated from a mouse immunized with a recombinant protein of human RAB14.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB14
Function Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion.
Cellular Location Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis
Research Areas

BACKGROUND

Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion.

REFERENCES

Proikas-Cezanne T.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Ren Y.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
Huang Y.-P.,et al.Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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