|Application ||WB, E|
|Calculated MW||28087 Da|
|Other Names||WW domain-binding protein 2, WBP-2, WBP2|
|Target/Specificity||This WBP2 antibody is generated from a mouse immunized with a recombinant protein between 1-261 amino acids from the C-terminal region of human WBP2.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WBP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1- responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus when phosphorylated|
Provided below are standard protocols that you may find useful for product applications.
Chen H.I.,et al.J. Biol. Chem. 272:17070-17077(1997).
Pirozzi G.,et al.J. Biol. Chem. 272:14611-14616(1997).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).