癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MMP1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P03956 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a |
| Clone Names | 1054CT20.4.3 |
| Calculated MW | 54007 Da |
| Gene ID | 4312 |
|---|---|
| Other Names | Interstitial collagenase, 3.4.24.7, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG |
| Target/Specificity | This antibody is generated from a mouse immunized with a recombinant protein from human. |
| Dilution | WB~~1:2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MMP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MMP1 |
|---|---|
| Synonyms | CLG |
| Function | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
Research Areas
BACKGROUND
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
REFERENCES
Templeton N.S.,et al.Cancer Res. 50:5431-5437(1990).
Whitham S.E.,et al.Biochem. J. 240:913-916(1986).
Goldberg G.I.,et al.J. Biol. Chem. 261:6600-6605(1986).
Lin D.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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