|Application ||WB, E|
|Calculated MW||82224 Da|
|Other Names||Serine/threonine-protein kinase DCLK1, 220.127.116.11, Doublecortin domain-containing protein 3A, Doublecortin-like and CAM kinase-like 1, Doublecortin-like kinase 1, DCLK1, DCAMKL1, DCDC3A, KIAA0369|
|Target/Specificity||This DCLK1 antibody is generated from a mouse immunized with a recombinant protein of human DCLK1.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCLK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DCAMKL1, DCDC3A, KIAA0369|
|Function||Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.|
|Tissue Location||In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.|
Provided below are standard protocols that you may find useful for product applications.
Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Omori Y.,et al.J. Hum. Genet. 43:169-177(1998).
Sossey-Alaoui K.,et al.Genomics 56:121-126(1999).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).