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NPPA Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - NPPA Antibody AM8592b
    Anti-NPPA Antibody at 1:2000 dilution + mouse heart lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 17 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01160
Reactivity Mouse
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1761CT158.12.76
Calculated MW 16708 Da
Additional info
Gene ID 4878
Other Names Natriuretic peptides A, CDD-ANF, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, Prepronatriodilatin, Atrial natriuretic factor, ANF, Atrial natriuretic peptide, ANP, NPPA, ANP, PND
Target/Specificity This NPPA antibody is generated from a mouse immunized with a recombinant protein of human NPPA.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNPPA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPPA
Synonyms ANP, PND
Function Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Cellular Location Secreted.
Research Areas

BACKGROUND

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

REFERENCES

Oikawa S.,et al.Nature 309:724-726(1984).
Nakayama K.,et al.Nature 310:699-701(1984).
Nemer M.,et al.Nature 312:654-656(1984).
Greenberg B.D.,et al.Nature 312:656-658(1984).
Seidman C.E.,et al.Science 226:1206-1209(1984).

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