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FNDC5 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - FNDC5 Antibody AM8591b
    Anti-FNDC5 Antibody at 1:2000 dilution + human skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 23 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8NAU1
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1736CT532.85.53.92
Calculated MW 23659 Da
Additional info
Gene ID 252995
Other Names Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2, Irisin, FNDC5, FRCP2
Target/Specificity This FNDC5 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 12-152 amino acids from human FNDC5.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFNDC5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FNDC5
Synonyms FRCP2
Function Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
Cellular Location Cell membrane; Single-pass type I membrane protein Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway.
Tissue Location Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen
Research Areas

BACKGROUND

Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.

REFERENCES

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bostrom P.,et al.Nature 481:463-468(2012).

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