|Application ||WB, E|
|Calculated MW||71192 Da|
|Other Names||Protein CBFA2T3, MTG8-related protein 2, Myeloid translocation gene on chromosome 16 protein, hMTG16, Zinc finger MYND domain-containing protein 4, CBFA2T3, MTG16, MTGR2, ZMYND4|
|Target/Specificity||This CBFA2T3 antibody is generated from a mouse immunized with a recombinant protein between 418-653 amino acids from human CBFA2T3.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBFA2T3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MTG16, MTGR2, ZMYND4|
|Function||Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.|
|Cellular Location||Isoform 1: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm|
|Tissue Location||Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).|
Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
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Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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La Starza R.,et al.Haematologica 86:212-213(2001).