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MYBBP1A Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - MYBBP1A Antibody AM8564b
    All lanes : Anti-MYBBP1A Antibody at 1:5000 dilution Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: A431 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 149 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9BQG0
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1702CT711.87.46
Calculated MW 148855 Da
Additional info
Gene ID 10514
Other Names Myb-binding protein 1A, MYBBP1A, P160
Target/Specificity This MYBBP1A antibody is generated from a mouse immunized with a recombinant protein between 1104-1328 amino acids from human MYBBP1A.
Dilution WB~~1:5000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYBBP1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYBBP1A
Synonyms P160
Function May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.
Cellular Location Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity) Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4}
Research Areas

BACKGROUND

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.

REFERENCES

Keough R.,et al.Genomics 62:483-489(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherl A.,et al.Mol. Biol. Cell 13:4100-4109(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).

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