|Application ||FC, E|
|Calculated MW||26277 Da|
|Other Names||Ras-related protein Rab-20, RAB20|
|Target/Specificity||This RAB20 antibody is generated from a mouse immunized with recombinant protein from human RAB20.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB20 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.|
|Cellular Location||Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity) Recruited to phagosomes containing S.aureus or M.tuberculosis|
|Tissue Location||Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).|
Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
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Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Seto S.,et al.Traffic 12:407-420(2011).