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MLL3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - MLL3 Antibody AM8552b
    Anti-MLL3 Antibody at 1:2000 dilution + Recombinant protein Lysates/proteins at 20 ng per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 541 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8NEZ4
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1686CT202.60.69
Additional info
Gene ID 58508
Other Names Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, 2.1.1.43, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3
Target/Specificity This MLL3 antibody is generated from a mouse immunized with a recombinant protein of human MLL3.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMLL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KMT2C
Synonyms HALR, KIAA1506, MLL3
Function Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
Cellular Location Nucleus.
Tissue Location Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver

BACKGROUND

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.

REFERENCES

Ruault M.,et al.Gene 284:73-81(2002).
Tan Y.C.,et al.Cancer Detect. Prev. 25:454-469(2001).
Hillier L.W.,et al.Nature 424:157-164(2003).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).

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