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>   首页   >   产品   >   一抗   >   神经科学   >   Tyro3 Antibody   

Tyro3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - Tyro3 Antibody AM8451b
    Western blot analysis of lysate from mouse brain tissue lysate, using Tyro3 Antibody(Cat. #AM8451b). AM8451b was diluted at 1:2000. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysate at 20μg.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P55144
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 1444CT895.86.31
Calculated MW 96208 Da
Additional info
Gene ID 22174
Other Names Tyrosine-protein kinase receptor TYRO3, Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF, Tyro3, Dtk, Rse, Tif
Target/Specificity This Tyro3 antibody is generated from a mouse immunized with a recombinant protein.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTyro3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tyro3
Synonyms Dtk, Rse, Tif
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Abundant in the brain and lower levels in other tissues
Research Areas

BACKGROUND

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

REFERENCES

Mark M.R.,et al.J. Biol. Chem. 269:10720-10728(1994).
Crosier P.S.,et al.Growth Factors 11:125-136(1994).
Lai C.,et al.Oncogene 9:2567-2578(1994).
Fujimoto J.,et al.Oncogene 9:693-698(1994).
Ohashi K.,et al.Oncogene 9:699-705(1994).

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