|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||92760 Da|
|Other Names||NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC|
|Target/Specificity||This Ntrk3 antibody is generated from a mouse immunized with a recombinant protein of human Ntrk3.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Ntrk3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1 (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads.|
Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1 (By similarity).
Yamauchi J.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:14421-14426(2003).
Menn B.,et al.J. Comp. Neurol. 401:47-64(1998).
Ballif B.A.,et al.J. Proteome Res. 7:311-318(2008).