The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.
PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Wang H, et al. Cancer Cell, 2010 Jul 13. PMID 20609352.
Constitutive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo. Matsukawa Y, et al. Pathobiology, 2010. PMID 20516731.
Prognostic and metastatic value of phosphatase of regenerating liver-3 in invasive breast cancer. Hao RT, et al. J Cancer Res Clin Oncol, 2010 Sep. PMID 20140626.
Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2. Min SH, et al. Life Sci, 2010 Jan 2. PMID 19945467.
PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. Peng L, et al. Mol Cancer, 2009 Nov 24. PMID 19930715.