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SOD2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - SOD2 Antibody AM7579a
    All lanes : Anti-SD Antibody at 1:2000 dilution Lane 1: Hela whole cell lysates Lane 2: human brain lysates Lane 3: human heart lysates Lane 4: human liver lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 25 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - SOD2 Antibody AM7579a
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SOD2 Monoclonal Antibody (Cat.#AM7579a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 1 - SOD2 Antibody AM7579a
    Western blot analysis of anti-SOD2 Monoclonal Antibody (Cat.#AM7579a) by SOD2-GST fusion protein (GST MW=26 kD. SOD2-GST fusion protein (arrow) was detected using the purified Mab. (1:2000)
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession P04179
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1κ
Clone Names 37CT127.5.11.6
Calculated MW 24722 Da
Additional info
Gene ID 6648
Other Names Superoxide dismutase [Mn], mitochondrial, SOD2
Target/Specificity Purified His-tagged SOD protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:2000
IHC-P~~1:10~50
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOD2
Function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Cellular Location Mitochondrion matrix.
Research Areas
Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells.
Author : Thomas-Jardin SE1,Kanchwala MS2,Jacob J1,Merchant S1,Meade RK1,Gahnim NM1,Nawas AF1,Xing C2,3,4,Delk NA1.
Prostate. 2018 Mar 11. doi: 10.1002/pros.23504. [Epub ahead of print]
29527701
Oxidative status predicts quality in human mesenchymal stem cells.
Author : Bertolo A1,Capossela S1,Fränkl G1,Baur M2,3,Pötzel T2,Stoyanov J4,5.
Stem Cell Res Ther. 2017 Jan 6;8(1):3. doi: 10.1186/s13287-016-0452-7.
28061861

BACKGROUND

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

REFERENCES

The sequence polymorphism of MnSOD gene in subjects with respiratory insufficiency in COPD. Pietras T, et al. Med Sci Monit, 2010 Aug 7. PMID 20802415.
Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus. Jones DA, et al. Diabetes Res Clin Pract, 2010 Aug 20. PMID 20728955.
Assessing oxidative pathway genes as risk factors for bipolar disorder. Fullerton JM, et al. Bipolar Disord, 2010 Aug. PMID 20712757.
Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis? Nahon P, et al. Antioxid Redox Signal, 2010 Aug 1. PMID 20673159.
Manganese superoxide dismutase versus p53: the mitochondrial center. Holley AK, et al. Ann N Y Acad Sci, 2010 Jul. PMID 20649542.

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