- 文献引用 : 2
|Application ||WB, E|
|Other Names||GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1|
|Target/Specificity||This Gab1 antibody is generated from mice immunized with a GST fusion protein encoding full length human GAB1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Gab1 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).|
Author : Fan YX1, Wong L, Marino MP, Ou W, Shen Y, Wu WJ, Wong KK, Reiser J, Johnson GR.
J Biol Chem. 2013 Jun 7;288(23):16895-904. doi: 10.1074/jbc.M112.434217. Epub 2013 Apr 23.
Author : Sun Y, Yuan J, Liu H, Shi Z, Baker K, Vuori K, Wu J, Feng GS.
Mol Cell Biol. 2004 Feb;24(4):1531-9.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany. Gao L, et al. Mol Carcinog, 2010 Oct. PMID 20602450.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control. McDonald CB, et al. Arch Biochem Biophys, 2010 Feb 15. PMID 20005866.