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AIM2 Antibody

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - AIM2 Antibody AM2210b
    Western blot analysis of lysate from NCI-H292 cell line, using AIM2 Antibody(Cat. #AM2210B). AM2210B was diluted at 1:1000. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysate at 20ug.
  • 1 - AIM2 Antibody AM2210b
    Western blot analysis of lysate from NCI-H292 cell line, using AIM2 Antibody(Cat. #AM2210B). AM2210B was diluted at 1:1000. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysate at 20μg.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O14862
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 812CT9.2.2.1
Additional info
Gene ID 9447
Other Names Interferon-inducible protein AIM2, Absent in melanoma 2, AIM2
Target/Specificity This AIM2 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 10-40 region of human AIM2.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAIM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIM2
Function Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Cellular Location Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles
Tissue Location Expressed in spleen, small intestine, peripheral blood leukocytes, and testis
Research Areas

BACKGROUND

Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

REFERENCES

DeYoung K.L., et al. Oncogene 15:453-457(1997).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Gregory S.G., et al. Nature 441:315-321(2006).
Cresswell K.S., et al. Biochem. Biophys. Res. Commun. 326:417-424(2005).
Chen I.-F., et al. Mol. Cancer Ther. 5:1-7(2006).

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