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>   首页   >   产品   >   一抗   >   癌症   >   LOX Antibody (Center)   

LOX Antibody (Center)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - LOX Antibody  (Center) AM2166b
    LOX Antibody (Center) (Cat. #AM2166b) western blot analysis in MDA-MB231 cell line lysates (35μg/lane).This demonstrates the LOX antibody detected the LOX protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P28300
Other Accession P16636, P45845, P28301, NP_002308.2
Reactivity Human
Predicted Mouse, Pig, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 624CT23.7.3
Calculated MW 46944 Da
Additional info
Gene ID 4015
Other Names Protein-lysine 6-oxidase, Lysyl oxidase, LOX
Target/Specificity This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLOX Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LOX
Function Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).
Cellular Location Secreted {ECO:0000250|UniProtKB:P28301}. Secreted, extracellular space
Tissue Location Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Research Areas

BACKGROUND

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

REFERENCES

Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18892-18897(2010)
Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :

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