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>   首页   >   产品   >   一抗   >   心血管   >   FGG Antibody (Ascites)   

FGG Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - FGG  Antibody (Ascites) AM2135a
    FGG Antibody (Ascites)(Cat. #AM2135a) western blot analysis in Hela cell line lysates (35μg/lane).This demonstrates the FGG antibody detected the FGG protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P02679
Other Accession NP_068656
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 546CT11.4.3
Calculated MW 51512 Da
Additional info
Gene ID 2266
Other Names Fibrinogen gamma chain, FGG
Target/Specificity This FGG antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 417-445 amino acids from human FGG .
Dilution WB~~1:200~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFGG Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGG
Function Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted
Tissue Location Detected in blood plasma (at protein level).
Research Areas

BACKGROUND

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

REFERENCES

Bahadori, B., et al. Thromb. Res. 126(4):350-352(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Fujihara, N., et al. Thromb. Haemost. 104(2):213-223(2010)
Undas, A., et al. Thromb. Haemost. 104(2):415-417(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)

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