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THBS1 Antibody (Center)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - THBS1 Antibody (Center) AM2131b
    THBS1 Antibody (Center)(Cat. #AM2131b) western blot analysis in MDA-MB231 cell line lysates (35μg/lane).This demonstrates the THBS1 antibody detected the THBS1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P07996
Other Accession P35448, P35441, Q28178, NP_003237.2
Reactivity Human
Predicted Bovine, Mouse, Xenopus
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 518CT18.12.8
Calculated MW 129383 Da
Additional info
Gene ID 7057
Other Names Thrombospondin-1, THBS1, TSP, TSP1
Target/Specificity This THBS1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 763-789 amino acids from the Central region of human THBS1.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTHBS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THBS1
Synonyms TSP, TSP1
Function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
Cellular Location Endoplasmic reticulum. Sarcoplasmic reticulum
Research Areas

BACKGROUND

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.

REFERENCES

Zhou, L., et al. Cancer Res. 70(20):8199-8210(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nucera, C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10649-10654(2010)
Gustavsson, H., et al. BMC Cancer 10, 288 (2010) :

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