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>   首页   >   产品   >   一抗   >   其他   >   GNAS Antibody (Ascites)   

GNAS Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - GNAS Antibody (Ascites) AM2129a
    GNAS Antibody(Ascites)(Cat. #AM2129a) western blot analysis in mouse brain tissue lysates (35μg/lane).This demonstrates the GNAS antibody detected the GNAS protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q5FWY2
Other Accession P29797, Q8R4A8, P63095, P63094, P63092, P04896, Q63803, Q6R0H7, Q5JWF2
Reactivity Mouse
Predicted Human, Rat, Bovine, Hamster, Pig
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 559CT 16.1.3
Calculated MW 44250 Da
Additional info
Other Names GNAS complex locus;GNAS;
Target/Specificity This GNAS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS.
Dilution WB~~1:300
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGNAS Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNAS
Research Areas

BACKGROUND

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

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