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JUP Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - JUP  Antibody (Ascites) AM2123a
    JUP Antibody (Ascites)(Cat. #AM2123a) western blot analysis in NCI-H292 cell line lysates (35μg/lane).This demonstrates the JUP antibody detected the JUP protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P14923
Other Accession Q6P0K8, Q8WNW3, Q02257, Q8SPJ1, NP_002221.1
Reactivity Human
Predicted Bovine, Mouse, Pig, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG3
Clone Names 606CT21.5.1
Calculated MW 81745 Da
Additional info
Gene ID 3728
Other Names Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
Target/Specificity This JUP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 636-663 amino acids from human JUP .
Dilution WB~~1:100~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJUP Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JUP
Synonyms CTNNG, DP3
Function Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Cellular Location Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form
Research Areas

BACKGROUND

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.

REFERENCES

Fressart, V., et al. Europace 12(6):861-868(2010)
Cabral, R.M., et al. J. Invest. Dermatol. 130(6):1543-1550(2010)
Aktary, Z., et al. Oncogene 29(14):2118-2129(2010)
Pryczynicz, A., et al. Folia Histochem. Cytobiol. 48(1):128-133(2010)
Czyzewska, J., et al. Folia Histochem. Cytobiol. 48(1):37-45(2010)

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