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HNF1A Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - HNF1A  Antibody (Ascites) AM2122a
    HNF1A Antibody (Ascites)(Cat. #AM2122a) western blot analysis in NCI-H460 cell line lysates (35μg/lane).This demonstrates the HNF1A antibody detected the HNF1A protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P20823
Other Accession P15257, P22361, NP_000536.4
Reactivity Human
Predicted Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 622CT11.9.6
Calculated MW 67356 Da
Additional info
Gene ID 6927
Other Names Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, Liver-specific transcription factor LF-B1, LFB1, Transcription factor 1, TCF-1, HNF1A, TCF1
Target/Specificity This HNF1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 177-205 amino acids from human HNF1A .
Dilution WB~~1:100~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHNF1A Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNF1A
Synonyms TCF1
Function Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:10966642}
Tissue Location Liver.
Research Areas

BACKGROUND

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.

REFERENCES

Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Ley, S.H., et al. Cardiovasc Diabetol 9, 39 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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