- 文献引用 : 1
|Application ||WB, E|
|Other Accession||P14628, P79182, NP_000567.1|
|Calculated MW||30748 Da|
|Other Names||Interleukin-1 beta, IL-1 beta, Catabolin, IL1B, IL1F2|
|Target/Specificity||This IL1B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 148-174 amino acids from the Central region of human IL1B.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL1B Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.|
|Cellular Location||Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins|
Author : Liu Y1,Wang W2,Zou Z3,Fan Q2,Hu Z3,Feng Z2,Zhu B3,Xiong J4.
Virus Res. 2017 Aug 28. pii: S0168-1702(17)30380-5. doi: 10.1016/j.virusres.2017.08.013. [Epub ahead of print]
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq].
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Gein, O.N., et al. Patol Fiziol Eksp Ter 1, 10-13 (2010) :