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CAT Antibody (Center) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - CAT Antibody (Center) (Ascites) AM2118a
    Anti-CAT Antibody (Center) (Ascites) at 1:1600 dilution + mouse liver lysate Secondary Goat Anti-mouse IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 59756 Da Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - CAT Antibody (Center) (Ascites) AM2118a
    Anti-CAT Antibody (Center) (Ascites) at 1:1600 dilution + K562 whole cell lysate Secondary Goat Anti-mouse IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 59756 Da Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P04040
Other Accession P04762, O62839, P24270, Q9PT92, P00432, NP_001743.1
Reactivity Human, Mouse
Predicted Rat, Zebrafish, Pig, Bovine
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 626CT4.3.8
Additional info
Gene ID 847
Other Names Catalase, CAT
Target/Specificity This CAT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human CAT.
Dilution WB~~ 1:1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCAT Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAT
Function Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Cellular Location Peroxisome.
Research Areas
Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.
Author : Pereira L1, Igea A, Canovas B, Dolado I, Nebreda AR.
EMBO Mol Med. 2013 Nov;5(11):1759-74. doi: 10.1002/emmm.201302732. Epub 2013 Sep 24.
24115572

BACKGROUND

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.

REFERENCES

Banerjee, M., et al. Toxicol. Appl. Pharmacol. 249(1):47-54(2010)
Wu, S.H., et al. Clin. Chim. Acta 411 (21-22), 1705-1710 (2010) :
Liu, L., et al. J. Invest. Dermatol. 130(11):2647-2653(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Dutkiewicz, G., et al. Nephrology (Carlton) 15(5):587-591(2010)

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