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ACE Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - ACE Antibody (Ascites) AM2111a
    ACE Antibody (Ascites)(Cat. #AM2111a) western blot analysis in mouse kidney tissue lysates (35μg/lane).This demonstrates the ACE antibody detected the ACE protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P12821
Other Accession NP_000780
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 536CT24.1.3
Calculated MW 149715 Da
Additional info
Gene ID 1636
Other Names Angiotensin-converting enzyme, ACE, 321-, Dipeptidyl carboxypeptidase I, Kininase II, CD143, Angiotensin-converting enzyme, soluble form, ACE, DCP, DCP1
Target/Specificity This ACE antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1274-1306 amino acids from human ACE.
Dilution WB~~1:500~16000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACE Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACE
Synonyms DCP, DCP1
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Cellular Location Angiotensin-converting enzyme, soluble form: Secreted
Tissue Location Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis
Research Areas

BACKGROUND

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.

REFERENCES

Dimitriou, G., et al. Pediatr. Pulmonol. 45(12):1233-1239(2010)
Ince, D.A., et al. Genet Test Mol Biomarkers 14(5):643-647(2010)
Procopciuc, L.M., et al. Eur. J. Intern. Med. 21(5):414-418(2010)
Ash, G.I., et al. Med Sci Sports Exerc (2010) In press :
Liu, L.W., et al. Chin. Med. J. 123(11):1382-1386(2010)

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