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>   首页   >   产品   >   一抗   >   精选抗体   >   G蛋白偶联受体抗体(GPCR)   >   MC1R Antibody (Center)   

MC1R Antibody (Center)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - MC1R Antibody (Center) AM2107a
    MC1R Antibody (Center)(Cat. #AM2107a) western blot analysis in A375 cell line lysates (35μg/lane).This demonstrates the MC1R antibody detected the MC1R protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q01726
Other Accession NP_002377.4
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 578CT6.2.3
Calculated MW 34706 Da
Additional info
Gene ID 4157
Other Names Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR
Target/Specificity This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMC1R Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MC1R
Synonyms MSHR
Function Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Melanocytes and corticoadrenal tissue.
Research Areas

BACKGROUND

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq].

REFERENCES

Demenais, F., et al. J. Natl. Cancer Inst. 102(20):1568-1583(2010)
Strange, R.C., et al. Mult. Scler. 16(9):1109-1116(2010)
Ibarrola-Villava, M., et al. Exp. Dermatol. 19(9):836-844(2010)
Smith, G., et al. Pharmacogenet. Genomics (2010) In press :
Kricker, A., et al. Cancer Causes Control (2010) In press :

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