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>   首页   >   产品   >   一抗   >   心血管   >   CD40 Antibody (C-term) (Ascites)   

CD40 Antibody (C-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - CD40 Antibody (C-term) (Ascites) AM2106a
    CD40 Antibody (C-term)(Ascites)(Cat. #AM2106a) western blot analysis in HL-60 cell line lysates (35μg/lane).This demonstrates the CD40 antibody detected the CD40 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P25942
Other Accession Q8SQ34, P27512, NP_001241.1
Reactivity Human
Predicted Mouse, Pig
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 647CT13.2.4
Calculated MW 30619 Da
Additional info
Gene ID 958
Other Names Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5
Target/Specificity This CD40 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human CD40.
Dilution WB~~1:100~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD40 Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD40
Synonyms TNFRSF5
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Cellular Location Isoform I: Cell membrane; Single-pass type I membrane protein
Tissue Location B-cells and in primary carcinomas.
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

REFERENCES

Rodriguez-Rodriguez, L., et al. J. Rheumatol. 37(10):2076-2080(2010)
Lewis, J.P., et al. Genomics 96(4):211-219(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Blanco-Kelly, F., et al. PLoS ONE 5 (7), E11520 (2010) :
Soliman, M.A., et al. Egypt J Immunol 16(1):61-70(2009)

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