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>   首页   >   产品   >   一抗   >   心血管   >   VTN Antibody(Ascites)   

VTN Antibody(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - VTN Antibody(Ascites) AM2089a
    VTN Antibody (Cat. #AM2089a) western blot analysis in T47D cell line lysates (35μg/lane).This demonstrates the VTN antibody detected the VTN protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P04004
Other Accession NP_000629.3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 389CT23.2.1.3
Calculated MW 54306 Da
Additional info
Gene ID 7448
Other Names Vitronectin, VN, S-protein, Serum-spreading factor, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B, VTN
Target/Specificity This VTN antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 352-379 amino acids from human VTN.
Dilution WB~~1:500~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVTN Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VTN
Function Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Cellular Location Secreted, extracellular space.
Tissue Location Plasma.
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Chillakuri, C.R., et al. FEBS Lett. 584(15):3287-3291(2010)
Sa E Cunha, C., et al. PLoS Pathog. 6 (5), E1000911 (2010) :
Kellouche, S., et al. Tumour Biol. 31(2):129-139(2010)
Singh, B., et al. Mol. Microbiol. 75(6):1426-1444(2010)

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